Document Type
Grant
Publication Date
9-1-2012
Department
Chemistry
Abstract
Previous research done on coprophi lous fungi has revealed the presence of secondary metabolites containing butenol ides sub-structures. These butenol ides show activity against the yeast Candida albicans. In efforts to further these investigations, the synthesis of butenol ide analogs was undertaken. The starting materials, 2-methylacryl ic acid and 1-penten-3-ol, were esterified in the presence of triethyl amine to form an ester, pent-1-en-3-yl-2-methylprop-2-enoate. The formation of ester was confirmed using 13C- NMR. The ester was then subjected to ring-closing metathesis in the presence of Grubb' s catalyst. The formation of the butenol ide was also confirmed using 13C-NMR. The product, 5-ethyl-3-methyl-2-(5H)-furanone obtained from this step has been purified using column chromatography. The butenol ide bioassay was done to test its activity against
Content Notes
Final Report Form, Poster, Research Report
Unique Identifier
gspstugrants_2013_Amatya_Neha
First Advisor
Sara Hein
