Effects of Water and Oxygen on the Structural Stability of RAPTA Complexes in Solvents Relevant to Biological Assays
Presenter(s)
Meagan Kaufenberg-Lashua
Abstract
Ruthenium-arene PTA (RAPTA) complexes represent a versatile class of organometallic compounds with promising pharmacological properties. In this study, we investigated how water and oxygen influence the structural stability of various RAPTA complexes in two solvents relevant to common biological assays: ethanol and dimethyl sulfoxide (DMSO). Assessment in chloroform, a common solvent for structural characterization, has also been conducted as a benchmark. NMR, UV-vis, and mass spectrometry were used to track solvolysis or hydrolysis. We have also explored how oxidized PTA, or protonated structures influence structural stability.
College
College of Science & Engineering
Department
Chemistry
Campus
Winona
First Advisor/Mentor
Joseph West; Jonathon Mauser
Location
Kryzsko Great River Ballroom, Winona, Minnesota; United States
Start Date
4-23-2026 1:00 PM
End Date
4-23-2026 2:00 PM
Presentation Type
Poster Session
Format of Presentation or Performance
In-Person
Session
2a=1pm-2pm
Poster Number
29
Effects of Water and Oxygen on the Structural Stability of RAPTA Complexes in Solvents Relevant to Biological Assays
Kryzsko Great River Ballroom, Winona, Minnesota; United States
Ruthenium-arene PTA (RAPTA) complexes represent a versatile class of organometallic compounds with promising pharmacological properties. In this study, we investigated how water and oxygen influence the structural stability of various RAPTA complexes in two solvents relevant to common biological assays: ethanol and dimethyl sulfoxide (DMSO). Assessment in chloroform, a common solvent for structural characterization, has also been conducted as a benchmark. NMR, UV-vis, and mass spectrometry were used to track solvolysis or hydrolysis. We have also explored how oxidized PTA, or protonated structures influence structural stability.
Comments
Kaufenberg-Lashua, Meagan M