Effects of Glial Cell Cycle Regulators In Drosophila melanogaster on Chemotherapy Induced Peripheral Neuropathy
Presenter(s)
Katelynn Warzonek
Abstract
Chemotherapy induced peripheral neuropathy (CIPN) is a prevalent side effect of chemotherapy. Cisplatin is a platinum-based chemotherapy drug that is known for neurotoxic effects. Drosophila melanogaster are a common model system due to having similar diseases related implicated genes as humans. RNA interference (RNAi) is used to down regulate specific genes leading to gene knockout. The goal of this study is to find which RNAi Drosophila strains are more resistant or sensitive to cisplatin effects on glial cells. Gene knockout of perineurial glial, subperineurial, and ensheathing glia on cyclin B and E were investigated.
College
College of Science & Engineering
Department
Biology
Campus
Winona
First Advisor/Mentor
Christopher Groen
Location
Kryzsko Great River Ballroom, Winona, Minnesota; United States
Start Date
4-23-2026 1:00 PM
End Date
4-23-2026 2:00 PM
Presentation Type
Poster Session
Format of Presentation or Performance
In-Person
Session
2a=1pm-2pm
Poster Number
71
Effects of Glial Cell Cycle Regulators In Drosophila melanogaster on Chemotherapy Induced Peripheral Neuropathy
Kryzsko Great River Ballroom, Winona, Minnesota; United States
Chemotherapy induced peripheral neuropathy (CIPN) is a prevalent side effect of chemotherapy. Cisplatin is a platinum-based chemotherapy drug that is known for neurotoxic effects. Drosophila melanogaster are a common model system due to having similar diseases related implicated genes as humans. RNA interference (RNAi) is used to down regulate specific genes leading to gene knockout. The goal of this study is to find which RNAi Drosophila strains are more resistant or sensitive to cisplatin effects on glial cells. Gene knockout of perineurial glial, subperineurial, and ensheathing glia on cyclin B and E were investigated.
Comments
Warzonek, Katelynn R