Document Type
Grant
Publication Date
9-1-2022
Department
Chemistry
Location
Winona, Minnesota
Keywords
Chemistry
Abstract
Prescription antidepressants are commonly used drugs to treat depression and many other disorders. It is known that enzymes metabolize most prescription drugs within the liver by altering them to become more polar to allow for easy excretion through the urine or bile. This study was done to determine the outcome of metabolism of six different tricyclic antidepressants (TCA’s): clomipramine, duloxetine, escitalopram, imipramine, nortriptyline, and venlafaxine. These six drugs were mixed with rat liver microsomes and an NADPH-generating system in a phosphate buffer at pH 7.4. All samples were incubated for two hours at 37°C.
First Advisor
Lee E. Myoung
COinS
