Document Type
Grant
Publication Date
9-1-2022
Department
Chemistry
Location
Winona, Minnesota
Keywords
Chemistry
Abstract
The serine/threonine protein kinases Mst2 and Mst1 are key members of the Hippo pathway, a signaling pathway that regulates apoptosis by inhibiting the transcriptional cofactor yes associated protein (YAP). 1 Mst2 is activated by phosphorylation at threonine-180, allowing it to phosphorylate large tumor suppressor kinases 1/2 (LATS1/2) which can then inhibit YAP. 1,2 The conformation of Mst2, particularly at the activation loop, is predicted to change when it is activated by phosphorylation. We believe that the stability and relatively small size of Mst2 may allow us to farther study its conformation using fluorescence-based techniques
First Advisor
Emily Ruff
COinS
