Preparation of Organoruthenium Complexes as Potential Cytotoxic Agents
Presenter(s)
Eion Hinkle
Abstract
RAPTA complexes and their precursors are an emerging class of therapeutic agents with potential cytotoxicity, making them candidates for cancer treatment. We have prepared a variety of organoruthenium compounds composed of a ruthenium core, a p-cymene, a β-diketone ligand, and a chloride or a 1,3,5-triaza-7-phosphaadamantane (more commonly known as PTA). Structures have been verified by 1H and 13C NMR (as well as 19F and 31P, when applicable) as well as by mass spectrometry. In a few select cases, single crystals suitable for X-ray diffraction analysis have been obtained enabling unequivocal structural determination. These compounds are currently under investigation by our collaborators for potential as antibacterial and anticancer agents.
College
College of Science & Engineering
Department
Chemistry
Campus
Winona
First Advisor/Mentor
Joseph West
Location
Kryzsko Great River Ballroom, Winona, Minnesota; United States
Start Date
4-23-2026 9:00 AM
End Date
4-23-2026 10:00 AM
Presentation Type
Poster Session
Format of Presentation or Performance
In-Person
Session
1a=9am-10am
Poster Number
35
Preparation of Organoruthenium Complexes as Potential Cytotoxic Agents
Kryzsko Great River Ballroom, Winona, Minnesota; United States
RAPTA complexes and their precursors are an emerging class of therapeutic agents with potential cytotoxicity, making them candidates for cancer treatment. We have prepared a variety of organoruthenium compounds composed of a ruthenium core, a p-cymene, a β-diketone ligand, and a chloride or a 1,3,5-triaza-7-phosphaadamantane (more commonly known as PTA). Structures have been verified by 1H and 13C NMR (as well as 19F and 31P, when applicable) as well as by mass spectrometry. In a few select cases, single crystals suitable for X-ray diffraction analysis have been obtained enabling unequivocal structural determination. These compounds are currently under investigation by our collaborators for potential as antibacterial and anticancer agents.
Comments
Hinkle, Eion D