Impact of Exercise on Drosophila Sensitivity to Chemotherapy Drugs
Presenter(s)
Wallace Whelan
Abstract
Drosophila melanogaster is a helpful model organism to understand human disease. In this experiment, cisplatin a chemotherapy drug that causes damage to neurons was fed to D. melanogaster. D. melanogaster was placed on an exercise regimen over the course of a few weeks to increase their resistance to the negative effects of the toxic stress of cisplatin or titanium compounds. Their ability to perform Negative Geotaxis Climbing Assays after being exposed to toxic stress provided data for the effectiveness of this protocol. The control flies were analyzed to attain a baseline for the Oregon Red phenotype then the subsequent trials were fed poisoned 10% sucrose solution with a Titanium compound Vs. Cisplatin to assess if flies that were on the exercise regimen climbed better than flies that did not exercise and exposed to Cisplatin and titanium compound.
College
College of Science & Engineering
Department
Biology
Campus
Winona
First Advisor/Mentor
Christopher Groen
Location
Kryzsko Great River Ballroom, Winona, Minnesota; United States
Start Date
4-23-2026 1:00 PM
End Date
4-23-2026 2:00 PM
Presentation Type
Poster Session
Format of Presentation or Performance
In-Person
Session
2a=1pm-2pm
Poster Number
73
Impact of Exercise on Drosophila Sensitivity to Chemotherapy Drugs
Kryzsko Great River Ballroom, Winona, Minnesota; United States
Drosophila melanogaster is a helpful model organism to understand human disease. In this experiment, cisplatin a chemotherapy drug that causes damage to neurons was fed to D. melanogaster. D. melanogaster was placed on an exercise regimen over the course of a few weeks to increase their resistance to the negative effects of the toxic stress of cisplatin or titanium compounds. Their ability to perform Negative Geotaxis Climbing Assays after being exposed to toxic stress provided data for the effectiveness of this protocol. The control flies were analyzed to attain a baseline for the Oregon Red phenotype then the subsequent trials were fed poisoned 10% sucrose solution with a Titanium compound Vs. Cisplatin to assess if flies that were on the exercise regimen climbed better than flies that did not exercise and exposed to Cisplatin and titanium compound.
Comments
Whelan, Wallace A