Preparation and Characterization of New Titanocene(IV) Curcuminoid Complexes

Abstract

Titanocene complexes and curcuminoid species have both independently been shown to exhibit a number of biologically relevant properties. While complexes of the type [(η5-cyclopentadienyl)Ti(β-diketonate)]+ have been reported, no curcumin-based analogue has ever been synthesized. Using a straight forward method, several [(η5-cyclopentadienyl)Ti("curc")]+ ("curc" = curcuminoidate) have been prepared using an array of synthetic curcumin analogues. 1H and 13C NMR spectroscopy, mass spectrometry and single crystal X-ray diffractometry have all been utilized to characterize these compounds.

College

College of Science & Engineering

Department

Chemistry

Campus

Winona

First Advisor/Mentor

Joseph West

Second Advisor/Mentor

Valeria Stepanova (Viterbo University)

Start Date

4-19-2023 10:00 AM

End Date

4-19-2023 11:00 AM

Presentation Type

Poster Session

Format of Presentation or Performance

In-Person

Session

1b=10am-11am

Poster Number

35

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Apr 19th, 10:00 AM Apr 19th, 11:00 AM

Preparation and Characterization of New Titanocene(IV) Curcuminoid Complexes

Titanocene complexes and curcuminoid species have both independently been shown to exhibit a number of biologically relevant properties. While complexes of the type [(η5-cyclopentadienyl)Ti(β-diketonate)]+ have been reported, no curcumin-based analogue has ever been synthesized. Using a straight forward method, several [(η5-cyclopentadienyl)Ti("curc")]+ ("curc" = curcuminoidate) have been prepared using an array of synthetic curcumin analogues. 1H and 13C NMR spectroscopy, mass spectrometry and single crystal X-ray diffractometry have all been utilized to characterize these compounds.