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The trifluoromethyl functional group is continuously finding application in various modern pharmaceuticals and agrochemicals.1,2 A previously reported synthesis of (Ph3P)3CuCF3, a robust, air-stable trifluoromethylating agent, was modified for an undergraduate laboratory followed by trifluoromethylation of an aryl iodide.3 This multiweek laboratory experiment introduces students to multi-step synthesis under air- free conditions to create an air-stable metal-CF3 complex, 79-86%yield. Trifluoromethylation was performed in an NMR tube with the utilization of a fluorinated chemical as an internal standard, which illustrated full conversion. Both targeted molecules were characterized via NMR (19F, 31P, 13C, 1H), and IR

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Presentation, Poster

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Joseph West



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