Document Type

Grant

Publication Date

9-1-2018

Department

Chemistry

Abstract

The trifluoromethyl functional group is continuously finding application in various modern pharmaceuticals and agrochemicals.1,2 A previously reported synthesis of (Ph3P)3CuCF3, a robust, air-stable trifluoromethylating agent, was modified for an undergraduate laboratory followed by trifluoromethylation of an aryl iodide.3 This multiweek laboratory experiment introduces students to multi-step synthesis under air- free conditions to create an air-stable metal-CF3 complex, 79-86%yield. Trifluoromethylation was performed in an NMR tube with the utilization of a fluorinated chemical as an internal standard, which illustrated full conversion. Both targeted molecules were characterized via NMR (19F, 31P, 13C, 1H), and IR

Content Notes

Presentation, Poster

First Advisor

Joseph West

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