Document Type
Grant
Publication Date
9-1-2018
Department
Chemistry
Abstract
The trifluoromethyl functional group is continuously finding application in various modern pharmaceuticals and agrochemicals.1,2 A previously reported synthesis of (Ph3P)3CuCF3, a robust, air-stable trifluoromethylating agent, was modified for an undergraduate laboratory followed by trifluoromethylation of an aryl iodide.3 This multiweek laboratory experiment introduces students to multi-step synthesis under air- free conditions to create an air-stable metal-CF3 complex, 79-86%yield. Trifluoromethylation was performed in an NMR tube with the utilization of a fluorinated chemical as an internal standard, which illustrated full conversion. Both targeted molecules were characterized via NMR (19F, 31P, 13C, 1H), and IR
Content Notes
Presentation, Poster
First Advisor
Joseph West
