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Mycobacterium tuberculosis, which is transmitted from human to human via respiratory droplets, is one of the leading killers among bacterial diseases in the human body (Center for Disease Control and Prevention, 2012). Although the cure for this disease is unknown, much advancement has been made in discovering one. A current focal point in research is how this bacterium produces ATP via menaquinone pathways, and how it is able to flourish even in stressful environments. We worked with a specific gene, Rv2173, which encodes for a product with an unknown chain length. It is believed that this product plays a role in the biosynthesis of menaquinone. Gas chromatography-mass spectrometry data indicated that the chain length of the product is 30 carbons long with a molecular weight of around 420. Discovering how menaquinone is synthesized can be useful because it can lead to the ability to target and inhibit synthesis, which Mycobacterium tuberculosis cannot survive without.

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Final Report Form, Poster

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Francis Mann



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