Document Type


Publication Date





Previous research done on coprophi lous fungi has revealed the presence of secondary metabolites containing butenol ides sub-structures. These butenol ides show activity against the yeast Candida albicans. In efforts to further these investigations, the synthesis of butenol ide analogs was undertaken. The starting materials, 2-methylacryl ic acid and 1-penten-3-ol, were esterified in the presence of triethyl amine to form an ester, pent-1-en-3-yl-2-methylprop-2-enoate. The formation of ester was confirmed using 13C- NMR. The ester was then subjected to ring-closing metathesis in the presence of Grubb' s catalyst. The formation of the butenol ide was also confirmed using 13C-NMR. The product, 5-ethyl-3-methyl-2-(5H)-furanone obtained from this step has been purified using column chromatography. The butenol ide bioassay was done to test its activity against

Content Notes

Final Report Form, Poster, Research Report

Unique Identifier


First Advisor

Sara Hein



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.