Document Type


Publication Date





“Parkinson’s Disease (PD) is a neurodegenerative disorder affecting approximately 1% of elderly Americans that results from progressive loss of dopaminergic neurons. Common motor symptoms of PD include resting tremor, rigidity, bradykinesia or akinesia and postural instability” (Zesiewicz et al., 2009). “Almost all patients with PD have non-motor and neuropsychiatric features, including sleep disturbances, compulsive and impulsive behaviors, autonomic dysfunction and psychosis” (Fernandez, 2012). In the years to come, as the average age increases the amount of PD patients will also increase due to the late onset of most PD cases. As the amount of PD cases caused by environmental factors decreases, the amount of genetic PD research may increase significantly. There are several different gene mutations that are believed to cause a form of inherited PD. “Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease” (Li et al., 2009). In this study we evaluated the appropriateness of the FVB/N-Tg(LRRK2*R1441G)135Cjli/J as a mouse model compared to the symptoms commonly seen in human PD LRRK2 patients and to those of the common reserpine induced model of PD.

Content Notes

Final Report Form, Research Report

Unique Identifier


First Advisor

Richard Deyo



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.