Synthesis, characterization, and exploration of binding mode preference for the complex of iron with the antibiotic cefdinir
Presenter(s)
Meagan Kaufenberg-Lashua and Alexander Gibbs
Abstract
Cefdinir is a common antibiotic used to treat an array of bacterial infections of the upper respiratory system. A common side effect observed in patients with high iron diets (typically formula-fed infants and supplemented geriatrics) is a distinctive non-bloody, red stool. This has been attributed to complexation of iron (III) by cefdinir. Cefdinir has multiple Lewis basic sites where iron could bind after deprotonation. The structure of the iron-cefdinir complex has been proposed with binding through the oxime group, however the structure has not yet been proven. An array of binding modes have been modeled to compare energies and predicted spectra (IR and UV-vis) alongside experimentally obtained spectra. Two different preparatory methods have been utilized providing distinctly different products bringing into question analyses from previous studies.
College
College of Science & Engineering
Department
Chemistry
Campus
Winona
First Advisor/Mentor
Joseph K. West
Start Date
4-24-2025 10:00 AM
End Date
4-24-2025 11:00 AM
Presentation Type
Poster Session
Format of Presentation or Performance
In-Person
Session
1b=10am-11am
Poster Number
36
Synthesis, characterization, and exploration of binding mode preference for the complex of iron with the antibiotic cefdinir
Cefdinir is a common antibiotic used to treat an array of bacterial infections of the upper respiratory system. A common side effect observed in patients with high iron diets (typically formula-fed infants and supplemented geriatrics) is a distinctive non-bloody, red stool. This has been attributed to complexation of iron (III) by cefdinir. Cefdinir has multiple Lewis basic sites where iron could bind after deprotonation. The structure of the iron-cefdinir complex has been proposed with binding through the oxime group, however the structure has not yet been proven. An array of binding modes have been modeled to compare energies and predicted spectra (IR and UV-vis) alongside experimentally obtained spectra. Two different preparatory methods have been utilized providing distinctly different products bringing into question analyses from previous studies.
Comments
No poster file.