Synthesis and characterization of cationic PTA complexes with ruthenium
Presenter(s)
Meagan M Kaufenberg-Lashua
Abstract
1,3,5-triaza-7-phosphaadamantane (PTA) is a tertiary, cage-like phosphine that is often used to increase the aqueous solubility of transition metal complexes, most notably in the well-studied class of ruthenium-arene PTA (RAPTA) compounds, extensively studied for their antitumoral activity. Increasing solubility and maintaining structure in an aqueous environment are two approaches we are currently pursuing to find more active species. We have prepared novel, cationic PTA complexes with ruthenium-cymene. These have been characterized by NMR, MS, IR, and UV-vis spectroscopies. Additionally, preliminary analysis of their biological activities against common bacteria have been conducted.
College
College of Science & Engineering
Department
Chemistry
Campus
Winona
First Advisor/Mentor
Joseph K. West
Second Advisor/Mentor
Jonathon Mauser
Start Date
4-24-2025 9:00 AM
End Date
4-24-2025 10:00 AM
Presentation Type
Poster Session
Format of Presentation or Performance
In-Person
Poster Number
35
Synthesis and characterization of cationic PTA complexes with ruthenium
1,3,5-triaza-7-phosphaadamantane (PTA) is a tertiary, cage-like phosphine that is often used to increase the aqueous solubility of transition metal complexes, most notably in the well-studied class of ruthenium-arene PTA (RAPTA) compounds, extensively studied for their antitumoral activity. Increasing solubility and maintaining structure in an aqueous environment are two approaches we are currently pursuing to find more active species. We have prepared novel, cationic PTA complexes with ruthenium-cymene. These have been characterized by NMR, MS, IR, and UV-vis spectroscopies. Additionally, preliminary analysis of their biological activities against common bacteria have been conducted.
Comments
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