Synthesis and characterization of cationic PTA complexes with ruthenium

Presenter(s)

Meagan M Kaufenberg-Lashua

Abstract

1,3,5-triaza-7-phosphaadamantane (PTA) is a tertiary, cage-like phosphine that is often used to increase the aqueous solubility of transition metal complexes, most notably in the well-studied class of ruthenium-arene PTA (RAPTA) compounds, extensively studied for their antitumoral activity. Increasing solubility and maintaining structure in an aqueous environment are two approaches we are currently pursuing to find more active species. We have prepared  novel, cationic PTA complexes with ruthenium-cymene. These have been characterized by NMR, MS, IR, and UV-vis spectroscopies. Additionally, preliminary analysis of their biological activities against common bacteria have been conducted.

College

College of Science & Engineering

Department

Chemistry

Campus

Winona

First Advisor/Mentor

Joseph K. West

Second Advisor/Mentor

Jonathon Mauser

Start Date

4-24-2025 9:00 AM

End Date

4-24-2025 10:00 AM

Presentation Type

Poster Session

Format of Presentation or Performance

In-Person

Poster Number

35

Comments

No poster file.

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Apr 24th, 9:00 AM Apr 24th, 10:00 AM

Synthesis and characterization of cationic PTA complexes with ruthenium

1,3,5-triaza-7-phosphaadamantane (PTA) is a tertiary, cage-like phosphine that is often used to increase the aqueous solubility of transition metal complexes, most notably in the well-studied class of ruthenium-arene PTA (RAPTA) compounds, extensively studied for their antitumoral activity. Increasing solubility and maintaining structure in an aqueous environment are two approaches we are currently pursuing to find more active species. We have prepared  novel, cationic PTA complexes with ruthenium-cymene. These have been characterized by NMR, MS, IR, and UV-vis spectroscopies. Additionally, preliminary analysis of their biological activities against common bacteria have been conducted.