Bioactivity assays of synthesized sulfanilamide-based imines.
Presenter(s)
Ella Ziel de Cruz, Elliott Bijnagte, Emily Roos, and Ashley Lopez
Abstract
We have examined the bioactivities of imines synthesized from sulfanilamide and aromatic aldehydes. Assays including disk diffusion and cell growth inhibition were performed on E. coli, P. aeruginosa, and S. aureus. In conjunction with this, optimized structures of these imines were docked with dihydropteroate synthase using SwissDock to determine relative binding energies. Comparisons between docking results and bioactivity assays were made to evaluate the correlation between binding affinities and antibacterial efficacy.
College
College of Science & Engineering
Department
Chemistry
Campus
Winona
First Advisor/Mentor
Jonathon Mauser
Second Advisor/Mentor
Joseph K. West
Start Date
4-24-2025 1:00 PM
End Date
4-24-2025 2:00 PM
Presentation Type
Poster Session
Format of Presentation or Performance
In-Person
Session
2a=1pm-2pm
Poster Number
35
Bioactivity assays of synthesized sulfanilamide-based imines.
We have examined the bioactivities of imines synthesized from sulfanilamide and aromatic aldehydes. Assays including disk diffusion and cell growth inhibition were performed on E. coli, P. aeruginosa, and S. aureus. In conjunction with this, optimized structures of these imines were docked with dihydropteroate synthase using SwissDock to determine relative binding energies. Comparisons between docking results and bioactivity assays were made to evaluate the correlation between binding affinities and antibacterial efficacy.
Comments
Add multiple authors to record; check presenter field