Development of a RAPTA complex synthesis and characterization lab for an upper-level inorganic chemistry course.
Presenter(s)
Celeste Remolina
Abstract
Ruthenium-arene-PTA complexes are rapidly garnering attention for their applications in medicinal chemistry. We have developed a multi-week teaching lab exercise conducted in CHEM 450 Advanced Inorganic Chemistry I in which students synthesize (p-cymene)(avobenzonate)(triazaphospha-adamantane)ruthenium(II) triflate as well as the triazaphosphaadamantane ligand itself. Characterization of the complex and ligand was completed using primarily NMR spectroscopy (1H and 31P) and mass spectrometry. Molecular modeling of NMR spectra have proven effective at the modest r2SCAN-3c level of theory, for accurately predicting chemical shifts. This lab development has paved the way for us to pursue new complexes with alternative β-diketonate ligands in lieu of avobenzone.
College
College of Science & Engineering
Department
Chemistry
Campus
Winona
First Advisor/Mentor
Joseph K. West
Start Date
4-24-2025 1:00 PM
End Date
4-24-2025 2:00 PM
Presentation Type
Poster Session
Format of Presentation or Performance
In-Person
Session
2a=1pm-2pm
Poster Number
45
Development of a RAPTA complex synthesis and characterization lab for an upper-level inorganic chemistry course.
Ruthenium-arene-PTA complexes are rapidly garnering attention for their applications in medicinal chemistry. We have developed a multi-week teaching lab exercise conducted in CHEM 450 Advanced Inorganic Chemistry I in which students synthesize (p-cymene)(avobenzonate)(triazaphospha-adamantane)ruthenium(II) triflate as well as the triazaphosphaadamantane ligand itself. Characterization of the complex and ligand was completed using primarily NMR spectroscopy (1H and 31P) and mass spectrometry. Molecular modeling of NMR spectra have proven effective at the modest r2SCAN-3c level of theory, for accurately predicting chemical shifts. This lab development has paved the way for us to pursue new complexes with alternative β-diketonate ligands in lieu of avobenzone.
Comments
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